I can easily see the Saints beating the favored Colts. If Sanchez and Edwards were able to make some big, easy plays, I don't really see any reason why Brees and his far more explosive weapons won't do the same. In addition, the Saints battered Farve, a QB who is more mobile than Manning. And speaking of, anyone see Manning just dive to the ground like a baby before getting sacked in the 1st quarter of last weeks game? Well, if that scared him, it'll only get worse.
At the end of the day, I think the Saints will come out on top with Manning still searching for his first legitimate Super Bowl win (thats right, I said first. Rex Grossman forfeited the 07' game to Manny, any opposing team would have won that day).