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http://www.nintendoworldreport.com/news/28908
Kid Icarus: Uprising will use the 3DS Circle Pad Pro, game director Masahiro Sakurai told Official Nintendo Magazine.
"The way we are using the Circle Pad Pro in the game is to provide support for left-handed gamers," explained Sakurai to Official Nintendo Magazine. "We've made it possible to use the right Circle Pad in place of the left one."
He also explained that "I didn't know the specs of the Circle Pad Pro, or what it looked like, until Monster Hunter 3G was announced, so we weren't able to do anything big with it in the time we had. Even if we had known about it from the start, I don't know whether we would have used both Circle Pads in that way."
The Circle Pad Pro will be released in North America on February 7. In Europe it will be released on January 27, and will come bundled with a copy of Resident Evil: Revelations. Kid Icarus: Uprising is set to release in North America on March 23.