Alright so the "Great American Video Game" has nothing to do with anything Japanese. Let's just get that out of the way right now. It's not Mario, it's not Zelda, it's not Metroid. Those are toys in fun worlds. The epitome of games has to be one that utilizes the medium's advantages well. In games you play the character through the world and story. Mass Effect gets closest to showing what games can be because not only is it an incredibly well-fleshed out world where every aspect is detailed (to the point where game mechanics are no longer game mechanics, they exist because they are arbitrated by the world and its components and they couldn't have existed any other way), you define the game by how you define your character. You create the protagonist and define how they interact with the surrounding world and characters. You then decide outcomes of plot points based on the character development you employed for the protagonist. This is the only medium that lets you do this. If you wanted to do this in any other medium you'd have to be a writer and write your own novels; even then you're only creating your own single protagonist for other people to enjoy.
That's why I never understood people docking the game because of regurgitated combat areas and other flaws. The game is the beginnings of the realization of the medium. The flaws just seemed to fall by the wayside in insignificance because I felt the impact of what was happening to my character and the weight of what my character had to decide, and I was just so engrossed in the world I didn't care about the repetition until my fourth playthrough. I used to play games because they were toys and I enjoyed seeing and playing improvements on genres as the years went by, and my interest in gaming was kind of waning until the ME games because they're just such a landmark in the progression of games. I wouldn't have called gaming a hobby for me until them; now I feel there is legitimate cause to claim that games are just as worthwhile as music, paintings, and novels, and Sands of Time was absolutely a major stepping stone for that.
I still play games because ultimately I'm mentally engaged in an interesting way. NSMBW was fun, but it doesn't hold up for long because of how second nature all the motions are, I don't have to think about it. I still find them fun, but I don't get to employ my imagination like I can with ME and like I used to do with Ninja Turtles and Ghostbusters toys. Which is ironic because I started by saying how ME is NOT a toy, but the way you imagine your character acting and feeling uses the same mental faculties as imagining the Turtles taking down Shredder with a calculated attack plan on the Sewer playset like I used to do as a kid. I think that's a testament to the game because it's enjoyable in very similar ways, but you also get a great sci-fi world and story along with it.
I think the best games can only come out of Western developers because, frankly, Japanese developers just don't get why people connect with stories and novels. It's usually some garbled muck with infinite strangeness that inevitably conveys how the power of friendship can overcome amnesia. If you can relate to that in a personal way, that's a great, unique thing, but that story holds no weight for me. Maybe a lot of Japanese people deal with that, I don't know, but I do think Western developers will continue to be the ones to push the medium as they have in recent years.