I don't think SKye is Jessica Drew at all. Nine times out of ten she's Coulson and May's daughter.
Did you run this through a scenario probability machine?
9x out of 10? Although I could see that also being a probability assuming they had a physical relationship like they almost alluded to earlier in the episode; "If you want I can lay out the mats downstairs and we can go a few rounds" (paraphrased), I'm not so sure.
(edit: it was also alluded to last episode - Skye: "Mom and dad are fighting downstairs"
let's hope that wasn't some foreshadowing - I would hope that Coulson would know that he had gotten May preggo and that May would have had SHIELD keep track of her daughter if she had to give her up. Fury at the very least would have known what was up. I really don't want to see a 'surprise!! we are your parents/I am your daughter' scene)
The whole missing parents, don't know who they are, working for a "Terrorist" organization, infiltrating SHIELD, ability to win over men (good looks or pheromones) against their better judgement, and the fact that we don't even know her real name or any of her history is all lining up with Jessica Drew at this point.
They've already established that there are people out there with special abilities (aka Scorch & The Clairvoyant), so it wouldn't be out of this world to think that Skye may have some dormant powers that she wasn't aware of or hadn't quite manifested yet.
Ward: "You can't save everyone from themselves" -
Coulson: "You can if you get to them early enough" (that comment could have had a double meaning.)
and i'm expecting alot more Freak of the Week episodes going forward as they try to locate the people on this short list before AIM decides to ramp them up into super beings. Besides I would love to see more of Reyna (actress Ruth Negga) preferably on screen the same time as Skye (actress Chloe Bennet)... so much eye candy in the last episode.