I think this thread will write itself in the other topics, but meh, I got a few minutes to burn.
1) Power. Still don't have an idea of the power of the Rev. (**Note: I will continue to call it the Rev until otherwise noted.) Not that I'm worried about this, but still. Have you seen the in-game footage of the newest Madden on the 360? Yea, looks like sh*t. Looks HARDLY better than the current gen. So if Nintendo can make good on the "2-3X Gamecube" figure, I'd say there will be little, if any, difference between all 3 systems.
2) Downloads. I wanted to know about this badly. I wanted to hear "400 games for download, more by the day as we secure more rights/companies." Also, how they save, can I transfer them to SD cards, etc. Also some info about updating classics. Goldeneye 64 online would attract COUNTLESS people, I can assure you.
3) Online service. We know it's wi-fi and some scant other details, need some meat quickly.
4) Third parties. We heard some comments from big name 3rd parties, but of course, given the nature of the controller, we all still, I'm sure, are very edgy about ports. I really, really hope Nintendo is driving support as hard as they can with cheap, affordable dev. costs and attractive license proposals.
5) Controller interfaces. I NEEDS teh info on teh shells, attachments, costs, everything, Ninty. A more "traditional" controller, eh? Will it come with the system? Be a pack in?
6) Games. NO TALK OF GAMES. MARIO 128's mechanics are said to be built on the Rev, so let's see it in action soon.
7) Indie/home brew. This is your perfect chance to strike on this, Nintendo. Let people make simple platformers and such for your system. There have been some really great ones lately online, no reason why you shouldn't be granting licenses for this sort of thing.

Number of simultaneous players for multiplayer? Probably 4, but that's just a guess.
Sure we got the controller, and that was HUGE and will buzz around in my head for days, but we're still seeing some characteristically Nintendo jedi-ness.
The cat is out of the bag, Ninty. Let's spill the rest.