Let's see. Assuming it's a Nintendo franchise because it's Nintendo Power, assuming it's got a connection to space because of the picture, and ruling out franchises based on games we already know about, that leaves five possibilities. "Most recognizable" rules out Earthbound and Pikmin, probably. F-Zero has recognizable characters, but isn't a character driven series, unless they actually want to put Captain Falcon in an adventure game. On the other hand, it's well established by now that Nintendo thinks Star Fox is a character driven series, but it can't be that because I refuse to believe it on the grounds that the universe hates me and would make sure I'm wrong. That just leaves Duke Kirby Forever. I just don't know.
It could also be some character they're sending into space for the first time, like they did to Mario. Maybe the mystery girl in the next Zelda is an alien. Maybe it's another disappointing Pokémon RPG. Maybe Little Mac's moving up to the Galactic Boxing Circuit.