Toys R Us is having a sale (until November 20) where you buy one and get one 40% off on all Wii, Xbox 360, and PlayStation 3 games.
They also have a bundle where you get the Mario 25th Anniversary DSi XL (which has Mario Kart DS), a copy of Mario vs. Donkey Kong: Mini-Land Mayhem!, and a red luxe case for $209.98, saving you $42.
Edit: The Best Buy Black Friday ad has been leaked, here are some of the good deals:
160GB PlayStation 3 with ModNation Racers, LittleBigPlanet Game of the Year Edition and a Blu-ray Disc copy of Cars for $300
4GB Xbox 360 with LEGO Batman: The Video Game, LEGO Star Wars: The Complete Saga. and LEGO Indiana Jones: The Original Adventures for $200
Fallout: New Vegas, Fable III, Halo: Reach, and the two-stick NHL Slapshot bundle are each gonna be $40.
Babysitting Mama, 007: Blood Stone, Def Jam Rapstar, and some Cabela hunting game I can identify will be $35
The PS3 version of Call of Duty: Modern Warfare 2, 360 version of WWE SmackDown vs. Raw 2011, and both console versions of Mafia II and Battlefield: Bad Company 2 will be $30.
The Xbox 360 and PlayStation 3 versions of Madden NFL 11, NHL 11, NCAA Football 11, FIFA Soccer 11, Need for Speed: Hot Pursuit, The Sims 3, Medal of Honor, and EA Sports MMA will be $35.