Props to you for mentioning Comix Zone.
Your idea is interesting, tho it reminds me more of Spy Vs. Spy for some reason...or perhaps Dungeon Siege is conceptually closer.
Lol, an Inspector Gadget game would work with that system...you got Mr. Evil overseeing his lair setting up those traps, and Tha Inspector using his abilities creatively to overcome them.
Good stuff.
-Blackknight131