Tom Nook from Animal Crossing. Man, that is one hot racoon.
Seriously, though, I don't remember any Nintendo made female who shows much more than face an hands--except Impa, but she could just pass for a man--, and thus there is insufficient information to determine "hotness." As for prettiest, though, Zelda in about any incarnation except the N64 adult one. That one has too much makeup.
Why do X-Box fans make that comment? Well, after you get a load of Master Chief's great hotness, you'd be looking down at anything that appeared on the GCN.