I doubt actually running the software would be that hard, since the Wii U is backward compatible with the Wii, and the Wii is just a suped up GameCube in terms of hardware. It takes a special kind of optical drive to read both the standard size discs and GC size discs, though, and I doubt Nintendo used that kind since they weren't going for BC. If they could figure out a way to do the controls for it, which would probably be pretty tough in its own right, I could see whatever homebrew community there is for Wii U supporting it through USB loaders, though.