Yes,
Or maybe a cold open to the movie of them on the spaceship just being a "family" (joking around, helping each other, usual friendly banter and conversation) while working on their individual research projects, when the radiation storm happens. Alarms and things go off, panic mode is activated as they try to dodge this sudden radiation storm that came out of nowhere.*blackout* chaos *blackout* screaming *blackout* quick clips of their experiments affecting their physical attributes (Johhny glowing red before he catches fire, Sue fading in and out of visibility, Ben swelling and then calcifying into a rock like substance, Reed melting and skin drooping into a puddle) and then more quick clips of the ship auto activating a return home protocol, heading back towards earth and then crash landing in the ocean.
*cut to Marvel logo and the opening intro credits*
then jump to 6 months later....
Everyone seems fine, life is carrying on as usual, Johnny looks normal and cracking jokes, Sue looks normal shaking her head at Johnny's stupid joke, Reed looks normal engrossed in whatever experiment he's working on, and then *thump*thump*thump* Ben "The Thing" Grimm enters the room, almost as big as the hulk making a half way joking threat to Johnny "You think you're such hot stuff Johnny boy, you better shut your trap or I'll clobber you".
Johnny Flames up.
Sue puts an invisible field intbetween the two
Ben accidentally knocks a shelf and a Large Vial of some liquid falls off the shelf
Reed reaches from 8feet away and grabs it just before it hits the ground telling them to take it outside because he's working in here.
*Jump to the Fantastic Four Logo*