Well, I finally beat it after putting it down for nearly 2 months. This may be the first time I've ever gone back to a game and beaten it. I always tell myself I'll do it, but I never do. (ie - every PS2 RPG I've attempted playing.)
In the end, I wasn't overly impressed with the story. I didn't really feel anything for Nico. Sure, he's dealt with a lot of crap in his past, but he became a horrible person. Roman was no angel, but he got over it. I felt really bad for Ma McReary. Two of her kids are dead, one's in jail, one's a smack addict, and the only one she has left is Packie. So sad.
I would've liked to see more missions with the McRearys. They were by far my favorite to work for. Three Leaf Clover was the most challenging mission in the game, and for all the right reasons, too. The dynamic among all the siblings was interesting to see. And the Blood Brothers mission was a very good choice on Rockstar's part. That was the only "choice" mission where I hesitated, but I think I made the right decision.
Overall, I'd give it a solid 9/10. It's not perfect by any means, but it was an awesome "next-gen" gaming experience. It wasn't as immersive as Mass Effect, it wasn't as innovative as Portal, but it did a lot of things right, and I can't wait for the DLC. I'm hoping to see some new friends, new activities, new islands, and then a bunch of new side missions to go along with all that.