I'm near the end of Okami now and it just gets better and better. The story had slowed down for a long time (also typical of a Zelda game) but it takes some VERY interesting turns towards the end. Okami's visual style and the brush techniques are its main innovations; the actual gameplay and structure of the game are totally ripped from the Zelda series, but what's interesting is how Okami mixes together elements from so many different Zelda games. There are obvious nods to Wind Waker, Ocarina, even Minish Cap. And did I mention that Okami is really long? I'm at 50 hours right now. That's with doing many side-quests along the way (they aren't bunched at the end like in Final Fantasy) but also consider that I'm very familiar with this kind of game and almost never get stuck on puzzles or where to go next.
Next time I get on the podcast, I'm going to demand a couple of minutes to pimp Okami. Anyone who enjoys the Zelda series would LOVE this game. So I figure that applies to the vast, vast majority of our readers.