Let me tell you something...a developer could create some sick twisted fun with Leasure Suit Larry, party mini games, and the Wiimote. I will just leave it right there.
But, you create a traditional Leasure Suit Larry game (nice point and click adventure with sexual humor) and then add in some sort of party game environment I think you have a winner purchase.
I also think a Leasure Suit Larry DS game with online and LAN multiplayer would be fun. Specially if you have a (hookup mode) where just walking around you can share friend information or something with other Leasure Suit Larry players.