yes. I don't know much about Superman comics myself, since I've never read one & I'm not a fan of Superman in general, but I'm a big Smallville fan (it start to fall apart somewhere around s5 an doesn't recover till s8. - <s9 just ended>)
I think it actually helps if you are unfamiliar with the mythos, but know who Superman is. Smallville covers from the beginning all the way up to his journey of becoming Superman, so you learn everything you need to during the show.