It's been years since Doki Doki Panikku brought Mario the ability to hold & throw items in a game. Now, we're able to throw frisbees and play Disc Golf with Lotion Puss.
It's about time we closed that generational gap and introduced action games where we can make our characters toss objects around to overcome obstacles and enemies and such. Maybe Mario can lob a turtle shell over a high wall, bank it off a farther wall, and strike a switch that was on the opposite side of the first wall that Mario obviously couldn't get to. Junk like that.
So not only are our hands more literally in the game (swinging swards or sports clubs, things we already know about), but our hands should affect the behavior of in-game objects with greater variety now (lobbing turtle shells, grenades, swinging a ball&chain, making waves on ropes or curtains or fabrics, scooping/carving material into various shapes, virtual whiteboard effects, playing catch, refined flashlight aiming, etc).
And it'll be much much more than "hold straight to turn right, turn right to crash into the siderail."