I'm going to take the fun route and list off some things that will be considered a fanboys dream than any prediction that might actually come true.
1. star fox wii: comes with a headset for online, in-game, chatting for co-op missions as well as multiplayer. The game will have free roam and linear levels, though linear levels will have more routes to take with different boss battles. This would be good for co-op since your team can split up and open up new paths to reach andross (or whomever the enemy is).
2. Mother wii: not a new game but remakes of all 3 mother games in one little package. The game will have more of 3D sprite look to it. Enhanced soundtrack as preorder bonus.
3. Goldeneye as a wiiware title, enhanced for online multiplayer*
4. DS-Wii connectivity announcement: GB/GBA games added to VC to be played at home or on the go.
5. Mario Artist announced for wii: dedicated game as opposed to a channel so it doesn't use up system memory, includes all 5 parts of the N64DD expansions, uses wiimote and ds for input. Example: draw a box or circle around an object you wish to draw on, the field you circled transfers to ds screen for zoomed in look for more precise drawing.
6. DS camera announced: finally get to put our face in games like we were meant to do in Perfect Dark, doubles as video chat for ds and wii games
and heres a non nintendo one: new Killer Instinct for 360 but it turns out sucky cuz Rare sucks
Remember i said in the beginning this was a fanboy wishlist and not a prediction of what we'll actually see