My predictions from Nintendo:
1.) A Zelda RPG game and/or another Mario RPG game, perhaps with the partnership of Square-Enix.
2.) A brand new 1st or 2nd party M-rated franchise to plug that hole and shut up Nintendo bashers who claim Nintendo only makes games for children.
3.) A 3rd person 3D or 2D Metroid game more in line with the older ones.
4.) An online MMORPG set in the Zelda or Mario universe. For as popular as these types of games are, Nintendo would be foolish not to make one.
5.) A DS revision that includes an SD card slot and allows the ability to play multimedia. Also includes built in Opera browser, Rumble capability, Tilt Pak, and online version of Pictochat and Mario Paint. In fact, you can save your Mario Paint works to the SD card to be printed or uploaded on your PC.
6.) A lightgun peripheral is announced for the Wii that looks and feels just like a real gun, but hooks up to the Nunchuck and works well for FPS type games. Plus this will come bundled with a game that makes good use of it, and this game will have a T or M rating to shatter Nintendo's kid only stereotype.
7.) We will see an Animal Crossing MMORPG for the Wii and perhaps a new version for the DS which will interoperate with the Wii version.
8.) Nintendo will announce a partnership with Youtube and/or Myspace for an exclusive Wii channel for their sites with special features.
9.) Nintendo will start offering music and video downloads on a Wii channel, which can be downloaded and accessed from both the Wii and the DS revision I proposed above.
10.) We will see a keyboard peripheral designed for the Wii and perhaps a mini-keyboard that plugs into the GBA slot of the DS for a more PDA feel.
11.) Reggie will be arrested for literally kicking someone's ass at the conference