They also talk about taking breaks in all of the instruction manuals nowdays, I think Perrin was just covering Nintendo's butt with that comment. It's the alternative to saying, "But don't sue us because you play games for hours on end and ignore all the obvious warning signs from your body." Personally I'm totally confident that the controller will be comfortable for long play times, although I think the button layout may turn out to be an issue... I'm unsure about the vertical alignment of the buttons and the d-pad on the remote. I think that will be more awkward than uncomfortable, though.
Edit: I saw Doshin while I was in Germany and I soooo wanted to buy it, but I don't know if there's a way to play PAL games on NTSC TVs. I don't think the surprises will be anything to spectacular, either, I especially don't think they'll bother porting any older titles except maybe Puzzle Collection at this point in time, but it's still nice to know that there are more games than they've announced.