I almost forget about this thread... well, we could use the right hand, but that would suck! try using your left hand, even for just pointing and clicking, is unconfortable, but I could get used to it...
Anyway, in the recent site of Nintendo DS Japan the first video in the "my first touch" section (Im so childish, I keep laughing at that title XD) has a left handed completly enjoying the game ^_^ Im less worried now.