I'd really really love to see a Wii-exclusive Gradius game, even if it were VC-only.
It would also be great if the paid homage to their first Nintendo-released Gradius game "Life-Force" by developing the game's controls to use the Wiimote "NES-style", while adding in further controls through motion gestures to result in different game effects like using super weapons, rewinding, etc.
Can't wait!