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AIM - Hate it, but a few of my friends use it...
Trillian.
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RealOne - I really like RealOne...what do you use for mp3/vid playback?
I despise it, just like all RealPlayers ever made. It's bloody useless spyware infested crap. I use Windows Media Player for vids, and Winamp for all audio.
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Quicktime - was already on my comp...never use it
It's ALMOST as bad as RealPlayer. The thing keeping it above is the lack of spyware, and the higher functionality. I still dislike it. Good man for not using it when possible.

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DivX Player - never use it, except in some rare cases I need to(like PGC vids)
Windows Media Player. Less buggy, faster.
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Windows Messenger - It's how I talk to Aussies! 
Trillian.
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Microsoft Outlook - I can't hide this for some reason...I might just delete it
I use webmail personally, but if I did use an email manager, I would use Thunderbird.

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Internet Explorer - It's easy to use, and it hasn't bothered me too much yet...I might change whenever I have more time... 
The most detestable of all programs ever made. Words simply cannot describe how much I HATE that program. God only knows why a browser from the f*cking STONE AGE is still the #1 most popular. Oh, I remember! PEOPLE ARE LAZY BASTARDS!!!!
Upgrade.