Eh, I really wouldn't enjoy a Retroactive devoted to RE4. I've said it before, but to me RetroActive is a feature that should be used to highlight the overlooked gems of the past and RE4 is certainly NOT that in any way, shape, or form. I just don't see what new discussion could come of a RetroActive on it that hasn't already been covered by countless sources over the better part of the last decade.
Now, I haven't played Infinite Space and I'm not going to since I don't own a DS, but that is the kind of game that belongs here (though I don't know if it would win given the growing vocal outcry against Strategy games constantly winning the polls).
I don't know if many people still own these games, but I'd like to nominate the second Lost Kingdoms GameCube game. It's a curious little action-RPG from back when the GameCube didn't have some of its better entries in the genre, and I don't know how many folks actually played it. Plus, with GameStop ceasing trade-ins on GameCube games, it feels fitting to highlight such a unique GC title in the near future.
That is, of course, unless it would be put in the same poll as Baiten Kaitos Origin's 2nd chance, because I really want that game to win one of those polls and it would split the vote.