Pretty much the only thing I'd like to see since Nintendo is inexplicably refusing to talk NX is news on Mother 3 and SMT x FE. Zelda Wii U could make an appearance, but I doubt it. We'll probably see Star Fox delayed. If Paper Mario was ever going to make an appearance, this would be the Direct for it (with more at E3).
Seriously, though, Nintendo: just reveal the NX. While you have that hanging over every public thing you do, nothing else you have really matters.