The draw of the Layton games to me has been the type of Sherlock Holmes type feel. That there is something beyond the possible going on, but by the time things wrap up, it's a bit more believable. The past Layton games do this a bit (although 'reality' is still a bit of a stretch).
If the Warner Bros want to make a Sherlock Homes games, they should steal this formula. It would be a perfect fit.