If you intend to get every trophy in Uncharted 1 and Platinum it you should play through it on Hard mode, because only by beating the game in Hard will you unlock Crushing and you need to beat it on Crushing in order to get all the trophies, so don't make the same mistake I made. I beat the game on Regular difficulty, but that doesn't unlock Crushing so now I have to beat it again on Hard and then again on Crushing which means I have to play the game 3 times in order to get everything.... ugh.
On the flipside, Uncharted 1 is not a long game, and if you play through it on a lower difficulty first you can use the cheats you unlock with the treasures on your Hard mode run. You can't use them on Crushing, though. Pity.
I recently replayed both Uncharted games as well through the dual pack, and while they certainly held up better than the first 2 Resistance games in
their dual pack (seriously, there was a time when
anyone thought the first Resistance was a good-looking game?)...I'm still not a fan of the first Uncharted. There's just too many rooms where you have to defend as wave upon wave of goons swarm at you. It just gets so tedious and monotonous, especially as you start having to backtrack a lot in the second half of the game.
Uncharted 2, though, is a masterpiece of pacing and action set pieces, so definitely look forward to playing that one. I have the same problem with the way it's last few chapters play out that I did with the original Uncharted, but I have pretty much no complaints with the rest of the game.