Here is some examples.
Gaunlet Wii:
Walk with the Analog Nunchuck. You can call circle menus around your character with Analog Buttons for Magic and item select. (Use pointer for quick select)
Now, swinging left, right, up, down, diagonal will allow you attack in that direction. This gives you the ability to attack monsters from any direction...but more importantly for Monsters to now come at you from any direction. This will make team work more important, and your long ranged character very valuable...but remember to protect them with the stronger melee characters so that you can move on as a team.
Attacks won't have to take broad swipes of movement, but instead, Point in the direction you want to attack and "Flick" the remote to attack. Different type attacks can be performed by holding down A/B buttons while attacking. Both buttons together can do special attacks, or throw enemies.
Similar controls could be used for something like River City Ransom Wii.
The coolness would come from being able to aim where you throw items, and enemies which will now have a weight given to them. Strategy comes from knowing how far you can throw items, as opposed to kicking them, or just attacking them straight out. Beatem Ups could begin to actually create more elaborate ways to beat enemies requiring you to use the environment to defeat your foes, and since the Wii control gives you ultimate freedom to direct your attacks so that the enemy hits the environmental hazards correctly.