Good article at 1up...
"1up Article"Some excerpts:
"I think arm fatigue is easy to pick on, but the bottom line is if a game is fun, you will play it well past the point where it's causing you physical pain. I still have scars on my thumbs from the NES controller that prove that. And I think Guitar Hero and DDR show that gamers are more than willing to actually stand and/or move their feet when the game requires it."
"BE: I think we would have to experiment with multiple control schemes. We would probably want to have one in which the player used the "nunchaku" for traditional movement and the Revolution controller for attacks and special abilities, as well as for camera control. Then we would also want to start from scratch and see if there were any new and innovative ways to use the Revolution's controllers within new control schemes to make the game more fun to play. Different players prefer different control schemes and a good game will always offer as many as possible to satisfy as many as possible."
Hopefully the second point gets embraced by most developers (although with tight budgets and schedules... :-/ )