Developing for 360/PS3 isn't bad business, it's just riskier business. You really have to know what you're doing and be confident that you're going to turn out a product that can stand alongside the big boys, and market it well to boot. There's less room for error, that's all.
The "folly" is that Midway sank tons of money into mediocre projects on high-investment platforms. That's simply bad management because they put all their eggs into one basket and didn't manage risk effectively. They'd didn't cover their asses with Cooking Mama: Mortal Kombat Edition for Wii, or Princess: My Life as a Queen for DS. Seriously, Blitz II, Wheelman, This Is Vegas? Who's going to buy those games?