DScaler is great if your video input hardware presents that interlacing problem. But if your hardware is like mine, say something made by Matrox or Pinnacle/Miro, then your video feed is already processing in an interlaced format via a special video overlay layer, so the scanline/interlace display problem is eliminated and there's no need for DScaler at all.
But if DScaler IS necessary for your situation and is used, videogames running at 60fps will experience quailty degredation: either it'll get cut to 30fps, or there'll be a mess of scanlines since I bet DScaler won't know what to do with a 60fps feed. This is due to a 60 fps video feed only displaying 60 unique interlaced fields each second (provided that you don't have expensive video capture hardware that accepts component video with progressive scan capture). Since the fields are unique, there are no progressive frames to recover, which means DScaler can't do its job: recovering progressive frames.