Realistically this could simulated by duct taping the Wii controller to a Nerf football.
I like how in the drawing the guy is doing a stiff arm when there would be absolutely no way for that the game to detect you doing that. But I guess the game is just so damn immersive that you'll do that instinctively until the game misinterprets your long bomb to the end zone as "spike the ball into the ground as hard as you can".
How the hell do you run with the ball unless you happen to have a 100 yard long living room? Well you move with the joystick, Ian! Oh so you're basically playing the same Madden you always have but you replace the throw button with waggle and add that extra risk of throwing your controller through your TV screen! YEAH!!!