I thought the second Sam & Max game got killed off shortly before its release? Or has it been given anoher chance?
After that cancellation, and the killed-off Full Throttle sequel (it didn't look that good, though), and Monkey Island 5 up in the air, I've been annoyed with LucasArts. I like Star Wars games but there seriously are too many of those now.
Maniac Mansion 3 and Grim Fandango 2 would be sweet, too, but those seem unlikely.