So that's a furry. I've heard it said before but never knew what it was. I can say 100% No. Allow me to explain...
In the Elder Scrolls games, one of the Daedric (essentially evil) gods is Sheogorath, the so-called 'Mad God'. He's quite a fan favorite. Anyway, in any Elder Scrolls game with him in it, there are quests you can do for him to get special weapons, such as the fabled 'Fork of Horripulation'. One of them is a metal rod called 'Wabbajack' that transforms any critter you hit with it. It could make a wolf into a cat, or a rat into an Ice Giant. So, no sin against nature half-humans, just normal animals.
Why try to amke a topic about this? What's more random then a metal stick that can turn you into an alligator? Of course, since no one here's a roleplayer here, it would be best to let this thread be washed away by the endless flow of topics in Ty's funhouse...