Again, I say it just depends on how much of a loss the price is.
If you are talking $25.00 or less a unit...it was just priced at a point to get those magic marketing numbers then it is not a problem. Nintendo can make it up big time on accessories and Nintendo really needs to get its system out there in large numbers year 1.
If we are talking $50-100.00 then that is very problematic. Specially closer to the $100.00 side.