I am not a fan of Binding of Isaac either, but I feel like there's probably a fan out there that can tell Gui what-for.
also, Please don't hate on Kirby Fans! :C
I think our tentpole 2018 release might actually be the Switch main line Fire Emblem that was promised, along with Pokemon, Shin Megami Tensei 5, and Octopath Traveler. Switch will be established as the new place for JRPG devs to find their footing. I also think that we're due for From Software's next title to show it's face to the world and be for all console platforms, as well as maybe... I dunno, a Tales of Xillia F?
This is where I get into the crazy crackpot theory time though.
See, I think with a fighter and a shooter, it's time for the third in this trilogy of eSports centered but goofy takes on things, and with that big Chinese MOBA coming, we get Nintendo's take on the MOBA, with copacitive touch/pointer control. it will, however, have a far different goal than most MOBAs to try and set it apart.
We finally start to hear the ideas of F-Zero being shopped around for a developer. HD rumble and being able to steer the console like a steering wheel being the catalyst of Miyamoto finding a decent enough reason to make a new F-Zero.
Sora LTD reveals they've found a way to make a single button, single Joycon only reboot of Stunt Race FX, including a cheesy saturday morning style plot where the cars talk to each other.
Nintendo publishes a Mega Man X remake with the graphics from the iOS version, but with the playable Vile from the PSP version, as well as a playable Zero who's so stupidly Overpowered that he trivializes the whole game. There's also a motion controlled Maverick busting mode where you hold your right joycon out like an arm cannon to carge shots and then thrust it forward to dash through the level in first person!
Ubisoft partners with Nintendo again for Rayman Warioware battle, Where Rayman has to play through 100 diabolical Wario games that all feature Microtransactions and pre-order bonuses of a collection of 'Iconic' caps!
Level 5 continues to have Nintendo publish Yokai watch games on 3DS.