Right, it's like getting accustomed to being a driver on the left side of the car in Amerikaland as opposed to right-side in Euroland. Everybody simply already learned it one way and is fine keeping it that way.
The UK and Ireland are the only European countries that drive on the left, the rest drive on the right (as does the majority of the world:
http://en.wikipedia.org/wiki/File:Countries_driving_on_the_left_or_right.svg). About 66% of the world drives on the right (vehicles are usually produced as left driving cars/driving on the right and right driving cars/driving on the left).
Anyways, I had no problem with the mirrored world of TP. Maybe it's because it's the only version I played and the fact that Nintendo clearly wanted the Wii version to be the primary version, but it felt natural and fine to me.