Epic just claimed that there's no middle ground between 50 million dollar AAA games and indie titles made in a garage. They're just close minded.
I'm going to go out and say that Epic's attitude, which is in part shared by many western developers is why Nintendo might never have a strong relationship with them the way they have with their Japanese counterparts. Instead of Nintendo crawling to them (the way Sony and Microsoft have done to a degree) and doing what they can to get their support, which can be a negative to Nintendo itself (looks at how much money Sony and Microsoft lost on their hardware doing that) Nintendo I think in a manner of speaking just does a "screw you too" and continues to do their own thing. They as a company are better for it I think even though we as customers might not be at times.
I think the N64/PS1 era when many developers pulled support (for various reasons) in favor of Sony taught Nintendo a valuable lesson. They can not and should not totally depend on 3rd party developers or have business models that put them in the red. Had Nintendo not had a good deal of their own IPs during the N64 and Cube era and had enough goodwill with buyers to introduce more they'd be gone I think. So they think about themselves first and foremost and what benefits them. As well as they should. They don't have the money to produce hardware so powerful and expensive that they need to sell at a loss just to get people to buy and so 3rd parties will make games for. It isn't going to happy. Neither would Sony or Microsoft if their gaming divisions were actual true independent entities.
I would much rather prefer Nintendo work with companies that actually are willing to work with the technology they provide. If they feel Nintendo could do better then I think they should work with them to design a system that will actually be profitable piece of hardware and not put Nintendo itself out of business. So instead of being concerned that Epic refuses to work on a Nintendo system I think more interest and support should be given to High Voltage who has a version of their Conduit engine running on the 3DS. People should be more interested in Capcom and Tecmo who has successfully developed Street Fighter and Dead or Alive games for the 3DS that are exactly like their console counterparts. Even Konami that is going to provide a true Metal Gear Solid game (remake it may be). Forget the likes of Epic I say.