Here are some of my predictions:
E3 2011:
Wii 2 is teased and Iwata walks out with a prototype Wii 2 controller and then proceeds to say that the Wii successor is on the horizon, but that we will have to wait for E3 2012 for more information.
Super Smash Brothers, Zelda, Metroid and Mario games for the 3DS will be slightly revealed with more information through out the year. Not sure whether they will get released in 2011, but more likly in 2012.
The Wii will get a $50 price drop to coincide with the holiday release of Skyward Sword. This in some sense would indicate that the Wii reign is closing.
Kid Icarus will not be a major success, but good enough that fans will want more and that the series hass made a farely good come back.
Gameboy Advance, Game Gear and Neo Geo Pocket Color will be made available for the 3DS virtual console along with remakes of Virtual Boy games for the 3DSware shop.
Sony and Microsoft will anounce a $50 price cut for the PS3 and 360 to coincide with their motion control systems and a robust holiday season.
Retro City Rampage will suffer the same fate as Super Meat Boy. If this comes to pass, I will be convinced that Wiiware, along with the Wii itself, is on the path of closing down.
Sequels to Epic Yarn, Epic Mickey, Goldeneye 007, Conduit 2, and galaxy 2 will be revealed as sequels for the 3DS at E3 2011.
Xenoblade and Last Story will be released in America in 2012 and will be the Wii's true sawnsong.
Dragon Quest 10 will be revelead at E3 2011 for the Wii this holiday season (I hope so).
3DS sports is shown at E3 2011 with walking, jogging, running and stair climbing as some of the sports.
Monster Hunter Portable 3 will be ported to the 3DS.
Sony shows off the PSP 2 at E3 2011.
Activision creates Call of Duty 3DS with a holiday 2011 release. This game will be unique in that it will allow 3D images to be made via the 3DS camera and then translated as the in-game vision mode of a Unmanned Aerial Vehicule used in the game. For example, I take a picture of my living room and the outline of my furniture is then translated as the outline for the terrain of the game.