The price may be justified, but that doesn't mean people are going to pay it. Look at the 3DS itself, or even the PS3...very cool items, but the price scared away even long-time customers. However, this is Resident Evil, so I'm sure it'll sell well...but I could also see people holding off until it goes on sale at some point down the line.
From a marketing standpoint, Capcom would be wise to throw in some type of cool swag to make the price go over a little easier; almost like a Collector's Edition without it being labeled as one.
This does make me wince, however. First off, the line "a true console experience on a handheld device" sounds very PSP-like, which automatically make me vomit in my throat a little. Second off, the fact that we're even seeing games this expensive being released for a handheld device in this day and age (not to mention economy) makes me vomit in my throat a little.