Just got this game. Like everyone says, it is awesome and you should go buy it ASAP.
On my second play-through now...

I've had non-gamer tendencies lately, but this brought me right back to my SNES days.
I have to echo everyone else's sentiments about the final battle
bossES for the losses, but it WAS super satisfying to finally best that jerk doctor. I actually kept Sue's annoying mutated self alive for the entire thing, just in case my killing her would kill her for good, just like poor Toroko. 
Also, there were flower petals in
Arthur's house. Was he the mimiga hero because... he was 'roid raging?!? =o