According to PDP, Sega's Conduit 2 will be "one of the first titles" to support the peripheral. There's no word as to whether or not the headset will work with other prominent titles like Monster Hunter Tri or Animal Crossing, but NWR has contacted PDP for more details.
Special thanks to DAaaman64 for the news tip!
Why can't Nintendo just release an update that allows USB microphones for computers and wireless blue tooth head sets to be used for the wii in place of wii speak?