Pretty sure we were promised a sequel to Detective Pikachu at some point, so my high-end expectation is that. I saw Sinnoh and "Diamond and Pearl" trending on twitter, but there's no chance that's happening this year.
My baseline expectations are info on Home and Sleep as well as some updates/events for SWSH. I think it's about time to launch Home.
Outside of that, a Smash reveal could easily be squeezed in with a gen 8 Pokemon, but it's a tough sell as a paid DLC fighter, especially in the current pack.
My unrealistic hope is a Pokemon Snap sequel.